Why a Genomic Test Like the Genomic Prostate Score® (formerly Oncotype DX GPS) test?

Understanding the GPS Basics

In this short 10 minute video, Senior Medical Liaison Ericka Bagi BSN, RN explains the development of the GPS assay and how the test evaluates adverse outcomes to help make treatment decisions for patients with low to high-risk prostate cancer.

 

Low grade doesn't equal low risk

Up to 30% of patients with low-risk prostate cancer experience a grade group shift after Radical Prostatectomy.1-3

GG = Grade group; GS = Gleason Score; RP = radical prostatectomy

Biopsies often do not accurately categorize risk because of tumor heterogeneity, multifocality, and undersampling in prostate cancer.4

More accurate measures of tumor aggressiveness lead to more treatment decisions.

GENETIC VS GENOMIC

Genetic tests screen for inherited risk factors or spontaneously arising mutations. They can help identify the risk of getting cancer or how a tumor may respond to certain therapies.5

Genomic tests examine gene expression levels within a sample of tumor tissue. They provide information about the tumor’s biology and aggressiveness.5

Edit Content
  1. Gearman DJ, Morlacco A, Cheville JC, Rangel LJ, Karnes RJ. Comparison of Pathological and Oncologic Outcomes of Favorable Risk Gleason Score 3 + 4 and Low Risk Gleason Score 6 Prostate Cancer: Considerations for Active Surveillance. J Urol. 2018;199(5):1188-1195.
  2. Ellis EE and Frye TP. Role of multi-parametric magnetic resonance imaging fusion biopsy in active surveillance of prostate cancer: a systematic review. Ther Adv Urol. 2022;14:1-15.
  3. Guimaraes T, Gil M, Medeiros M, Andrade V, Guerra J, Pinheiro H, Fernandes F, et al. Magnetic resonance imaging target fusion biopsy vs. transrectal ultrasound-guided biopsy – A comparative study of ISUP score upgrading risk in the final radical prostatectomy specimen. Arch Ital Urol Androl. 2022; 94(3):278-284.
  4. Mehralivand S, Shih JH, Harmon S, et al. A grading system for the assessment of risk of extraprostatic extension of prostate cancer at multiparametric MRI. Radiology. 2019;290(3):709-719.
  5. Brooks MA, Thomas L, Magi-Galluzzi C, et al. GPS assay association with long-term cancer outcomes: twenty-year risk of distant metastasis and prostate cancer-specific mortality. JCO Precis Oncol. 2021;5:PO.20.00325.