MDxHealth Epigenetic Biomarkers Identify Men at Increased Risk of Prostate Cancer Recurrence
NEWS RELEASE / REGULATED INFORMATION / INSIDE INFORMATION
ABSTRACT #490, POSTER SESSION 36
Data presented at EAU 2017 shows potential to improve personalized treatment
IRVINE, CA, and HERSTAL, BELGIUM - 07:00 CET, March 27, 2017 - MDxHealth SA (Euronext: MDXH.BR) today announced that results from a prospective study demonstrate that biomarkers from its ConfirmMDx® for Prostate Cancer test could help urologists monitor therapy response to improve the personalized treatment of castration resistant prostate cancer (CRPC).1 CRPC is an aggressive form of the disease that doesn't respond to traditional, hormone deprivation therapies. The study findings were presented at the 2017 European Association of Urology (EAU) Annual Congress in London, England.
Researchers from Radboud University Medical Center and Ghent University found that men with CRPC (n=47) had higher concentrations of plasma cell-free DNA (cfDNA - fragments floating outside of cells in the bloodstream), and higher levels of methylation of the biomarkers detected by the ConfirmMDx for Prostate Cancer test, versus a control group (n=30) of healthy people.1 DNA methylation, used by cells to control gene expression and hypermethylation of specific genes, is a hallmark of many cancers and has been shown to predict cancer progression.
"The prognosis for men with CRPC is poor, with median survival times ranging from 9 to 22 months," said Prof. Dr. Jack Schalken, study investigator and Research Director, Radboud University Medical Center, Department of Urology, Nijmegen, The Netherlands. "The identification of reliable biomarkers for CRPC will ultimately help urologists to more effectively stratify patients in this population to receive the treatment that will provide the greatest potential for extending life."
In this study, the median levels of cfDNA of men with CRPC were significantly higher than in the age-matched controls and men <35 years of age (p<0.01).1 Hypermethylation of GSTP1 was observed in 91% of men with CRPC at baseline, prior to treatment initiation, and significantly higher than in both male control groups (p<0.02).1 Methylated APC was also higher in men with CRPC at baseline versus the control group (p<0.01).1 Patients were stratified into four groups to assess overall survival according to cfDNA concentration at baseline and GSTP1/APC response to treatment with chemotherapy, abiraterone or enzalutamide. The group with both samples below the median had significantly less prostate cancer-related deaths (p<0.02).1
"MDxHealth's research collaborations help us to discover new applications for biomarkers to expand our portfolio of molecular diagnostics for uro-oncology," said Dr. Jan Groen, CEO of MDxHealth. "This study is another strategic milestone in our ongoing development of liquid biopsy products to help urologists detect prostate cancer recurrence and assess treatment response."
MDxHealth is a multinational healthcare company that provides actionable molecular diagnostic information to personalize the diagnosis and treatment of cancer. The company's tests are based on proprietary genetic, epigenetic (methylation) and other molecular technologies and assist physicians with the diagnosis of urologic cancers, prognosis of recurrence risk, and prediction of response to a specific therapy. The Company's European headquarters are in Herstal, Belgium, with laboratory operations in Nijmegen, The Netherlands, and US headquarters and laboratory operations based in Irvine, California. For more information, visit mdxhealth.com and follow us on Twitter at: twitter.com/mdxhealth.
For more information:
Shalon Roth, EVP Corporate Communications
UK: +44 (0)7393 906278
- Hendriks R, et al. (2017) Cell free DNA methylation markers as predictors of treatment response and prognosis for castration-resistant prostate cancer. European Association of Urology (EAU) Annual Meeting. Abstract #490. 26 March 2017.
This press release contains forward-looking statements and estimates with respect to the anticipated future performance of MDxHealth and the market in which it operates. Such statements and estimates are based on assumptions and assessments of known and unknown risks, uncertainties and other factors, which were deemed reasonable but may not prove to be correct. Actual events are difficult to predict, may depend upon factors that are beyond the company's control, and may turn out to be materially different. MDxHealth expressly disclaims any obligation to update any such forward-looking statements in this release to reflect any change in its expectations with regard thereto or any change in events, conditions or circumstances on which any such statement is based unless required by law or regulation. This press release does not constitute an offer or invitation for the sale or purchase of securities or assets of MDxHealth in any jurisdiction. No securities of MDxHealth may be offered or sold within the United States without registration under the U.S. Securities Act of 1933, as amended, or in compliance with an exemption therefrom, and in accordance with any applicable U.S. securities laws.
NOTE: The MDxHealth logo, MDxHealth, ConfirmMDx, SelectMDx, AssureMDx and PredictMDx are trademarks or registered trademarks of MDxHealth SA. All other trademarks and service marks are the property of their respective owners.